Manchester City, Arsenal suffer European blues
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In the other group the only outstanding issue was settled as Russian side Zenit St Petersburg withstood enormous pressure from already qualified seven-time champions AC Milan to win 1-0 away in Italy and take third place and a Europa League spot at the expense of Anderlecht.
Manchester City were undone by Julian Schieber, who crowned his first Champions League appearance of the season to score Dortmund's winner when he slotted home from a brilliant low cross by Polish star Jakub Blaszczykowski in the 57th minute. It left City's outstanding goalkeeper Joe Hart seething.
"I would love to be able to answer why we have been so poor in Europe this season but I can't. All I know is that we have to address it," said Hart.
Real Madrid eased to victory over Ajax with Brazilian star Kaka's superb effort making him the most prolific all-time Brazilian scorer in the Champions League with 28 edging ahead of fellow 2002 World Cup winner Rivaldo.
Real coach Jose Mourinho said that he wasn't disappointed with their overall group campaign.
"Well we emerged from the Group of Death and there will be plenty of teams who topped their groups who will not wish to be drawn against us," said Mourinho.
Arsenal's hopes of keeping their 1-0 lead to the end - thanks to Tomas Rosicky's first goal since March - never looked likely as they had failed to keep a clean sheet on their five previous visits to Greece.
Sure enough goals in the second-half by Giannis Maniatis and substitute Kostas Mitroglu ensured the hosts gained a second successive home win over their opponents, having beaten them 3-1 at the same stage last season.
Wenger took the defeat on the chin, something he is having to get used to of late. "We had a good first half but dropped physically in the second. Many of the players are not used to that level. We have to wait for the draw but ideally you would want to finish first."
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