South Africa strike back with late wickets
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It was the returning Watson (1-22) who claimed the initial breakthrough, having Graeme Smith caught at first slip by rival skipper Michael Clarke for 16.
Watson made a welcome return from a calf problem, having missed Australia's last eight home Tests with various injuries, by finding a thick outside edge from Smith to remove the Proteas skipper.
Just before lunch, Starc (2-55) struck two telling blows.
Starc removed opener Alviro Petersen (30) when he bowled the right-hander with a full delivery and then found a way through the defence of Kallis (2), who overcame a hamstring injury to take his place in the match, with a similar ball.
Already struggling at 63 for three at lunch, the Proteas crumbled after the resumption, with Hashim Amla (11), AB de Villiers (4) and debutant Dean Elgar (0) all falling in quick succession.
Amla was run out by a brilliant direct hit from David Warner in the covers, de Villiers became Hastings' first Test scalp when caught at first slip by Clarke and Elgar gave Johnson (2-54) a well-deserved first wicket when he was caught behind.
Robin Peterson (31) and Philander (30) offered support to du Plessis, while Lyon picked up late wickets with his off-spin to claim 3-41.