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Australia all-rounder Shane Watson, who missed the first Test, has been battling to prove his fitness from a calf injury.
A decision will be made on Wednesday or the morning of the match on his inclusion, but former captain Ricky Ponting said Watson could not play if he was anything less than 100 per cent fit.
"There will be a certain amount of running he will have to do to prove that he's right to play a Test match," Ponting said Tuesday.
"No one can go into a Test match 70 per cent fit. I don't care if you're a batsman and a slip fielder. If you can't bat at 100 per cent, then you are putting pressure on other blokes as well."
Rookie batsman Rob Quiney, who was added to the squad when Watson pulled out of the series opener in Brisbane, is expected to play if Watson fails to prove his fitness.
Local spinner Nathan Lyon, who took four wickets in the first Test, is expected to bowl plenty of overs on his home ground, which is renowned for big totals.
Australian coach Mickey Arthur has likened the Adelaide wicket to those on the subcontinent.
"Adelaide's been pretty consistent, Adelaide's a very, very good wicket," he said.
"You know what you get, it's almost like the subcontinent. It's very slow for the first three days then quickens up towards the back end.
"It goes from being the best batting wicket in the world to being pretty difficult to bat on in days four and five. So, big first innings are the way to go there."
South Africa last won in Adelaide in January 1964, beating Bobby Simpson's team by 10 wickets. They have subsequently lost two and drawn one at the Oval.
The final Test starts in Perth on November 30.
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